PhD Thesis/ UM6P-Cedoc - Benguerir

Enseignement - Secteur Enseignement / Formation

  • Moins de 1 an
  • 1 poste(s) sur Marrakech et région - Maroc
  • Bac +5 et plus

Extraversion Organisation Respect des règles Besoin de réflexion Recherche de nouveauté

Publiée il y a 19 jours sur - Postuler avant le 16/01/2022

Entreprise :

Mohammed VI Polytechnic University is an institution dedicated to research and innovation in Africa and aims to position itself among world-renowned universities in its fields. The University is engaged in economic and human development and puts research and innovation at the forefront of African development. A mechanism that enables it to consolidate Morocco’s frontline position in these fields, in a unique partnership-based approach and boosting skills training relevant for the future of Africa. Located in the municipality of Benguerir, in the very heart of the Green City, Mohammed VI Polytechnic University aspires to leave its mark nationally, continentally, and globally. 

ISSB-P is an institute specialized for biological and medical fields with Research and Education missions. The institute is acting in 4 research axes: Molecular and Cellular Biology, Biomaterials and Nanomaterials for medical & drug delivery applications, Epidemiology, and Machine Learning applied in Biological and Medical Sciences. Our professors and researchers are experts in their fields, as well they work in a transversal and cross-disciplinary way, in association with world’s leading researchers, aiming at the development of new tools for personalized medicine, nanomedicine and biotechnology. ISSB-P take part of the large-scale research and development dynamic focusing on research in current and highly relevant topics with clinical purposes relating to cancer, neuroscience, protein production including monoclonal antibodies for diagnosis and therapeutic purposes, and immunology and cell biology.  The mission of the institute is to support research from fundamental basics to clinical application that increases understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment, and prevention as proficient as providing innovative solutions in medical and biological research.

Poste :

PhD Thesis project: Effect of phosphorus on immune system and the gut microbiota interaction and their consequence on the development of inflammatory diseases.




Increasing evidences from human and animal studies show that nutritional and microbial factors during a critical window of opportunity early in life are required to prevent pathologies development later in life such as allergy, inflammatory bowel diseases, cancer and metabolic-related diseases. Recently, it has been revealed that a vigorous immune response induced by intestinal microbiota during weaning period is required to prevent increased susceptibility to chronic inflammatory diseases in adult mice (Al Nabhani et al., Immunity 2019). Phosphorus (P) is an essential nutrient for both microbes and their host, as it is involved, for example, in bone formation, energy metabolism, cellular signaling and stabilization of cell membranes.


Given the close relationship between specific microbial metabolites and expression of cytokines (Metzler-Zebeli et al, J Nutr 2012), interactions between intestinal microbiota including their metabolic activities, the integrity of the epithelial barrier function, the immune system, and the P content of the diet can be assumed. Furthermore, results from other vertebrate species indicate that dietary deficiency of P may negatively affect lymphocyte function, cytokine secretion and anti-body production. Stratification and compartmentalization, for example, are the main immunological mechanisms preventing the host from colonization with intestinal pathogens, and both strongly depend on IgA production and cytokine secretion by intestinal immune cells. In an immune-compromised host, however, these mechanisms might be reduced. Reduced lymphocyte function, because of low P availability, might therefore negatively affect the host’s ability to prevent intestinal colonization by pathogens.


Our proposal aims to address the following questions 1) to define the microbial factors mediated by the P dietary during early in life that predict pathological imprinting; 2) to determine the immune cells that carry a healthy or pathological imprinting at long-term under P dietary ; 3) to identify at molecular, metabolic and epigenetic level the underlying mechanisms of the immune memory induced by P treatment; 4) to develop therapeutic measures that induce a healthy weaning reaction or target the pathological imprinting. To this end, we will use transgenic mouse and gnobiotic model, reversible bacterial colonization, metabolomics, epigenetic, DNA cytosine methylation, single-cell transcriptome and high-throughput sequencing technologies. These studies will decipher how nutrition control microbiota and instruct the immune system and impact inflammatory diseases in adulthood and thereby will provide targets for preventive and therapeutic measures against diseases development.








Al Nabhani, Z. et al. A Weaning Reaction to Microbiota Is Required for Resistance to Immunopathologies in the Adult. Immunity 50, 1276–1288.e5 (2019)




Metzler-Zebeli BU, Ga ?nzle MG, Mosenthin R,et al. (2012)Oatb-glucan and dietary calcium and phosphorus differen-tially modify intestinal expression of proinflammatorycytokines and monocarboxylate transporter 1 and cecalmorphology in weaned pigs.J Nutr142, 668 – 674






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Lot 660, Hay Moulay Rachid, Ben Guerir 43150

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Extraversion Organisation Respect des règles Besoin de réflexion Recherche de nouveauté

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